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Biochemical Role in Preclinical Research Reported non-clinical work has examined the peptides interaction with the nitric oxide system, including its counteraction of nitric oxide synthase inhibition in preclinical models

However, as detailed above, cells that exhibit higher levels of mitochondrial activity are less sensitive to 5FU treatment, and those with compromised mitochondrial function are more sensitive, correlating with intrinsic resistance

Another three models for covariate adjustments were constructed to evaluate potential differences in the confounding effects