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Diabetes is characterized by chronic systemic hyperglycemia, which activates several secondary metabolic pathwayssuch as the polyol pathway, accumulation of AGE products, and protein kinase C (PKC) activationthat contribute to retinal and systemic vascular damage [67]

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In this context, various flavones and flavonols containing a catechol moiety in their B-ring with o -diphenols have been reported as strong competitive inhibitors of tyrosinase 94,99,100,101,102 , which is associated with tyrosinase inhibition 99