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The damage induced by hyperglycemia was generally regarded as results from a series of chain reactions triggered by inflammatory responses, leading to increased activity of the transcription factor NF-B

Genetically, ASD can be linked to identifiable genetic syndromes, such as Fragile X, Tuberous Sclerosis, Neurofibromatosis I, ADNP syndrome, and copy number variations (Lubbers et al., 2024

Insulin resistance fuels this process, worsening metabolic dysfunction, hyperglycemia, and lipid dysregulation, which further strain the cardiovascular, renal, hepatic, and metabolic systems (22, 23)

This enzyme converts a molecule called 5,10-methylenetetrahydrofolate to a molecule called 5-methyltetrahydrofolate