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1B, smokers have a partial deterioration of endothelial function, with a similar severity as in patients with hypercholesterolemia, with the presence of both risk factors (hypercholesterolemia and smoking) leading to a significant and severe deterioration of endothelial function [36]

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OxS and the formation of advanced glycation end products act as the link between inflammation and bone resorption (Pietschmann et al., 2016)