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This stepwise titration lets you monitor tolerance while gradually reaching the effective dosing levels observed in preclinical research [1] [4]

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This makes it a systemic glow support product not a spot treatment

The Leyden 2002 clinical evaluation in the Journal of Cosmetic Dermatology compared a copper tripeptide cream and serum against placebo in 67 women with photodamaged skin and found significant improvements in wrinkle depth, skin laxity, clarity, and density at 12 weeks [30]