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Although inflammation can be a protective response, sustained activation of neuroinflammatory pathways leads to neuronal injury and causes the progression of neurodegenerative disorders ( 2.5 Impaired protein degradation systems Dysfunction in systems responsible for protein degradation, such as the ubiquitin-proteasome system (UPS) and autophagy, contributes to the development of AD and PD

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Many PASC patients (89%) report CV symptoms including chest pain (53%), palpitations (68%), and new onset of postural orthostatic tachycardia syndrome (POTS, 31%) 193