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72 These findings suggest that subnormal ALP levels may be a useful diagnostic tool for HPP, that PLP levels may be useful in patients with a suspected diagnosis of HPP, for screening family members to detect possible heterozygotes, and to monitor response to therapy

These studies further demonstrated that loliolide-treated HDP spheroids secretes VEGF, IGF, and KGF, and the culturing of HaCaT keratinocytes using conditioned media from loliolide-treated HDP spheroids increased the proliferation and migration of keratinocytes 9 [65]