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Of note, pantothenic acid (formerly vitamin B 5 ) is the precursor of coenzyme A, and pyridoxine (vitamin B 6 ), in the form of pyridoxal-5'-phosphate, is required for the conversion of tyrosine to 4-hydroxyphenylpyruvic acid that constitutes the first step in the biosynthesis of the benzoquinone structure of coenzyme Q 10

The molecular core of this pathway, elucidated over the last decade, consists of RCAR/PYR1/PYL receptors, PP2C phosphatases, and SnRK2 kinases (Fujii et al