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For example, studies based on animal models of inflammatory or neuropathic pain have found that selective positive modulators of 2 and 3 subtypes of GABA-A receptors may reverse the loss of postsynaptic GABA-A receptor-mediated spinal cord inhibition, leading to analgesia (102)

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However, it has gained attention for treating acid reflux because it reduces the frequency of transient lower esophageal sphincter relaxations (TLESRs)