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In addition to altered T cells subpopulation (significantly more Th1 and Th17 cells), increased proinflammatory cytokines such as IFN-, IL2, IL6, TNF-, MCP-1, and MIP-1 also point to the role of an autoimmune reaction in PD pathogenesis [210, 211]

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Conversely, a randomized single-blind, three-period measurement in smokers showed that exposure to nicotine-free electronic cigarettes did not lead to acute changes in cardiovascular oxidative stress parameters

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