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TLR2 activation increases CYP1A1 activity in the intestines, which, in turn, can help with the detoxification of ingested toxicants.[ref] Medications metabolized using the CYP1A1 enzyme: Olanzapine[ref] Granisetron Fast and slow CYP1A1 metabolism: There are several genetic variants of CYP1A1 that can change the speed at which your body will metabolize substances