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Potential risks Serious risks and adverse events include: Allergic reaction to the medications or dye used in the injection Shoulder infection Depigmentation of the skin around the injection site (a whitening of the skin) Local fat atrophy around the injection site (thinning of the skin) Rupture of a tendon located in the path of the injection Nerve damage near the shoulder joint Bleeding at the injection site In addition to the above, corticosteroid injections increase the risk of: High blood pressure High blood sugar Decreased immune function Decrease in bone mineral density Bone infection (osteonecrosis) Reproductive hormone imbalance Metabolic changes (eg, increased appetite, weight gain, and fluid retention) These risks are typically associated with higher doses of corticosteroids, multiple injections, and for people with underlying medical conditions such as diabetes and heart problems

Some painful knee conditions require more immediate treatment for full recovery, and is therefore important to have your knees evaluated promptly by a medical doctor at a pain treatment center

So taking it in a multivitamin is best, unless you have been diagnosed with a deficiency

If you are already on semaglutide and feeling sluggish, a B12 boost could help you stay energized while you navigate through challenges