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Recent work from Thompson and colleagues showed that Rae-1, one of the ligands for NKG2D, was expressed by certain populations of endothelial cells at steady state (116)

The weekend break allows receptor resensitization while the consistent weekday dosing provides therapeutic benefit

Both can potentially exacerbate this condition

Additionally, among SASP factors, there are growth factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and insulin-like growth factor 1 (IGF-1), which, when secreted into the environment by senescence cells, stimulate the repair and regeneration of surrounding tissues [13]