Abstract Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and as a result, disturbances in GSH homeostasis are implicated in the etiology and/or progression of a number of human diseases, including cancer, diseases of aging, cystic fibrosis, and cardiovascular, inflammatory, immune, metabolic, and neurodegenerative diseases
They are: Vitamin B1 Vitamin B2 Vitamin B6 Vitamin B12 Vitamin B9 Zinc Magnesium Selenium Vitamin E Vitamin C Alpha lipoic acid These vitamins, minerals and antioxidants play a number of roles: They trigger the glutathione enzymatic system They enable glutathione production by directing cysteine, and increasing cellular uptake of cysteine They participate in the formation of glutathione from its precursor amino acids They help reactivate glutathione, transitioning it from its oxidized state back to its active state They maintain the balance of oxidized and active glutathione They are in turn activated by glutathione and each other, allowing for a robust presence of antioxidants Without these 11 cofactors, glutathione would not be as plentiful, as active, or as efficacious
Regul Pept 1996;67:123-30
When consumption is low or there is a malabsorption of vitamin C, scurvy, a rare disease may appear
