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Key monitoring markers: IGF-1 levels (GH axis response) Fasting insulin and glucose (metabolic impact) hsCRP (inflammatory trajectory) Body composition (DEXA or InBody) Subjective quality: sleep depth, energy, recovery speed, cognitive clarity What the Evidence Supports and What It Does Not Intellectual honesty is part of good clinical practice

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Xu and colleagues addressed the limited clinical impact of TPZ, they designed a novel class of urea-containing TPZ derivatives