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Those stimulants present problems, particularly in training camp where strenuous activity generates heat in the body, and that could form a dangerous combination." According to a 2006 New York Times story, the NFL performs about 10,000 tests for performance-enhancing drugs to about 1,800 players each year

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The fact that mutant ATXN3 aggregates are also found in axons and that components that ensure protein homeostasis are in close proximity led to the hypothesis that the aggregation process occurring within axons may affect mechanisms of axonal transport of mRNA, proteins, and organelles and thereby contribute to a wider neuronal dysfunction in SCA3 [30]