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Substituting histidine at position 2 with other residues dramatically reduces copper-binding affinity and alters the complex's properties

It is derived from a protein sequence originally identified during research involving gastric proteins, leading scientists to investigate its biological properties under controlled laboratory conditions

BhattaraiYWilliamsBBBattaglioliEJWhitakerWRTillLGroverMet alGut microbiota-produced tryptamine activates an epithelial G-protein-coupled receptor to increase colonic secretion

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