Legaki E, Dovrolis N, Moscholiou N, Koutromanos I, Vassilopoulos E, Dakanalis A, Gazouli M, Tzavellas E (2024) Altered expression of neuroplasticity-related genes in alcohol addiction and treatment
Learning latency was significantly pronounced in both male and female mice treated with intranasal saline, with much slower escape times and a lower magnitude of improvement, validating the naturally occurring cognitive decline of these mice
Clinical and postmortem studies consistently demonstrate reduced BDNF expression and diminished neurogenic capacity in individuals with depression, while effective antidepressant treatments, including SSRIs, SNRIs, and electroconvulsive therapy, restore neurogenesis and promote neuronal maturation
Its availability is limited to research markets, and using it in humans carries both legal and health risks