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The vast number of data-poor new and existing inhalable substances, including ambient or occupational exposure-related chemicals/substances, pharmaceuticals, and consumer and commercial products, as well as mixtures of different substances, and repeated exposure scenarios precludes the feasibility of using traditional in vivo animal studies to evaluate the potential adverse effects of these exposures and scenarios ( Toxicity Testing in the 21 st Century: A Vision and a Strategy , outlined a strategy to address these limitations through the use of in vitro and computational new approach methodologies (NAMs) to advance the throughput and human relevance of toxicity testing

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