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Agarwal R, Green JB, Heerspink HJL, et al

Additional studies using the ASBT inhibitor volixibat in LDLr leiden knockout mice supported that conclusion and demonstrated a significant decrease in diet-induced Non-alcoholic fatty liver disease activity score by the inhibition of ASBT (55)

In short, the gut microbiota influences brain function via the regulation of neurotransmitters and neurotrophic factors, maintenance of intestinal barrier and tight junction integrity, activation of enteric sensory afferents, production of bacterial metabolites, and modulation of mucosal immune responses [22]

This selectivity has allowed Tate and coworkers to estimate that about 65%, 60%, and 95% of S -methyl-cysteinylglycine-hydrolyzing activities of the rat renal, jejunal, and epididymal membranes are due to cysteinylglycine dipeptidase (reviewed in Tate, 1989)