Milk thistle, which significantly increases glutathione and improves the ratios of reduced and oxidized glutathione
For instance, insulin resistance affects 5080% of women with PCOS, while impaired glucose tolerance and type 2 diabetes occur in 35% and 10% of cases, respectively
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Copeland AR, Bueso-Ramos C, Liu FJ, Kornblau SM , Huh YO, Albitar M