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Erythrocytes from knock-out mice that do not express the energy-sensing enzyme AMPK are significantly more susceptible to the eryptotic effect of energy depletion than erythrocytes from wild-type littermates expressing normal levels of AMPK [149]

Despite promising preclinical results and its favorable safety profile, BPC 157 lacks FDA approval, necessitating further clinical trials to validate its therapeutic potential and establish comprehensive safety data

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