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These factors predominantly include the frequent consumption of sugar-sweetened beverages, ultra-processed foods, and diets high in saturated fats, which promote weight gain and chronic low-grade inflammation (158)

Nowadays, the probability of opportunistic fungal infection is increasing due to the increasing number of patients with weak immune function who are undergoing organ transplantation, chemotherapy, antibiotic therapy, and immunosuppressive drugs (dexamethasone and IL-6 inhibitors, etc.)

Major side effects rarely occur, but an allergic reaction causes severe side effects

In the present study, serum and liver levels of NO were reduced by treatment with sildenafil and the combination of sildenafil and vitamin E