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Integrative strategies that complement peptide therapy include gut barrier repair with glutamine, zinc carnosine, and probiotics, mast cell modulation with quercetin, vitamin C, and DAO support, nervous system repair with magnesium threonate, omega-3s, and vagal-tone therapies, and anti-inflammatory nutrition using whole-food diets rich in polyphenols and minerals

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Conversely, the ubiquitin ligase E3 HUWE1/MULE, which acts as a negative regulator of ferroptosis, regulates iron metabolism by targeting transferrin receptor 1 and counteracts abnormal iron accumulation, thereby alleviating acute liver injury caused by hepatic ischemia-reperfusion (I/R) [34]

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