However, existing research still faces issues such as insufficient reliability in demonstrating clinical causal relationships, overreliance on animal models, and inadequate elucidation of underlying mechanisms
In addition, it was reported that the cells with higher expression levels of auxin response factor (ARF) were more susceptive to ferroptosis, as ARF could inhibit the ability of NRF2 to activate its target genes, including SLC7A11 (Chen et al., 2017)
Huang 2023
It is naturally produced in nearly every cell of the body and plays a central role in: Neutralizing free radicals that cause oxidative stress and cellular damage Supporting liver detoxification , particularly in Phase II detox pathways Regulating the immune system , helping balance inflammation and defense Repairing DNA and proteins , essential for anti-aging and longevity Because of its central role in cellular defense, glutathione is often called the master antioxidant. However, levels can drop due to aging, chronic stress, poor diet, toxin exposure, or genetic variants like MTHFR , which can limit glutathione recycling
