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Drug Interactions: The clinical trials did not specifically evaluate interactions between AOD-9604 and other medications

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Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype

Some patients may see longer-lasting results, but maintenance treatments are recommended to keep the hands youthful and smooth