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FIGURE 5 3.7 Anti-menopausal symptoms Menopause is characterized by the perturbation of the hypothalamic-pituitary-gonadal axis, including decreased estrogen levels, dysregulation of neurotransmitter such as serotonin, dopamine, and norepinephrine and an increase in the levels of the catabolic enzyme, monoamine oxidase A (MAO-A)all of which have been implicated in depressive symptoms and vasomotor instability (Table 1, Row 23) (Figure 5B)

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Due to the half-life of the dsRNA, the effectiveness of RNAi gradually weakens with an increasing length of time after treatment, so there may be a discrepancy in the life events (such as laying and hatching of eggs) after engorgement of ticks

Both oxygen consumption and total daily expenditure, but not RER, were significantly increased in animals treated with SR4 compared with the control (Fig