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During ferroptosis, lipid radical formation is induced by the accumulation of ROS leading to plasma membrane lipid peroxides (Jiang et al., 2021)

Specifically, we and other groups have reported that detached and metastasizing OVCA cells are especially vulnerable to ferroptosis 9,10,11,12 , a form of cell death characterized by iron dependency and an irreversible accumulation of lipid hydroperoxides 13

Controlled release of silyl ether camptothecin from thiol-ene click chemistry-functionalized mesoporous silica nanoparticles

Note: The blue nucleotides represent the restriction enzyme sites (Eco RI, BamHI), the red nucleotides indicate the USS sequence, and the orange segment denotes the KanR overlap region