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Look for symptoms of vitamin B12 deficiency Symptoms of low levels of vitamin B12 include: Anemia Fatigue Neuropathy Neurological decline Glossitis, or swelling of the tongue Low counts of white and red blood cells Dementia Weight loss Infertility Your body can store vitamin B12
(Read our Ask An Expert article on the MTHFR gene for further information.) Methylfolate, the active form of folic acid, plays a role in converting homocysteine into methionine, an essential amino acid in humans
The diagnosis of vitamin B12 deficiency typically relies on low total B12 levels and elevated concentrations of homocysteine (Hcy), as well as levels of transcobalamin-bound B12 (holoTC) and methylmalonic acid (MMA), which serve as functional indicators of cobalamin insufficiency (Carmel and Sarrai, 2006)
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