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In colorectal cancer, DHRS7-deficient tumors presented with an immunosuppressive TME, characterized by increased regulatory T cells and diminished activity of cytotoxic T cells, resulting in accelerated tumor advancement [17]
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Moreover, iPLA2, a member of the calcium-independent phospholipase A2 family, functions independently of glutathione by cleaving oxidized fatty acid chains from phospholipids, directly removing peroxidized products, effectively detoxifying damaged lipids, and maintaining membrane integrity ( In summary, lipid peroxidation is central in ferroptosis, driven by ROS-mediated oxidative damage to PUFAs in cellular membranes
The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders
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