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PLOS ONE 9 , e115888 (2014)

Surgery for spinal stenosis should be considered only after other conservative therapies have been exhausted because it is usually not as successful as hoped and leads to a new diagnosis failed back surgery syndrome, where symptoms continue to deteriorate

In the 2 years after the publication of proof of principle with ketamine, registered clinical trials were initiated investigating the oral therapies riluzole and memantine, which were initially developed for other indications (Fig