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Although this study has systematically elucidated the therapeutic efficacy and mechanisms of GPS in various diseases, its clinical translation still faces significant challenges

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in this case, individuals show a limited or generalized deficiency of GSH and an accumulation of 5-oxoproline (in blood and cerebrospinal fluid) leading to metabolic acidosis [43], mental retardation, neuropsychiatric dysfunction, spinocerebellar degeneration, peripheral neuropathy, myopathy, hepato-splenomegaly, hemolytic anemia, aminoaciduria, and severe neurological complications [134]

(A, B) Cells were incubated with FITC-Annexin V conjugate and PI after SFN exposure for 24 or 48 h respectively