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2024;202 doi: 10.1016/j.phrs.2024.107115

Since the Lewis lung carcinoma (LLC) model is the only reproducible syngeneic model for NSCLC [15], we deemed it is appropriate for determining the effect of IGF1R deficiency on key components of the TME, not only using an experimental pulmonary metastasis model but also upon heterotopic syngeneic transplantation

Nevertheless, cancer cell line transplantation models remain well-suited to certain investigations, particularly when a large number of BM is required